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Analysis of the Adverse Drug Reaction (Glyprin)

 

This Article wrote by pharmacy student. Some information may not accurate

 

SCHOOL OF PHARMACEUTICAL SCIENCES

 

 

UNIVERSITI SAINS MALAYSIA

Drug information clerkship

 

Title: Analysis of the Adverse Drug Reaction

(Glyprin)

 

Academic Session 2009/2010

Department of Pharmacy, HUSM

 

Clerkship Date: 4 October – 8 October 2009

Clerkship Group: Group B (HUSM)

Preceptor: Puan Khairul Bariah

 

 

Report Prepared by:

MARZUKI ABDUL HAMID

90343

 

Introduction

Glyprin is a combination of aspirin (100mg) and glycine (45mg). It is used to treat transient ischaemic attacks,  secondary prevention of myocardial infarction (MI) & for prophylaxis against stroke, vascular occlusion & deep vein thrombosis.  Salicylic acid properties of aspirin make this drug can be used to relieve pain and fever. This drug is actually can be classified as an antiplatelet, anticoagulant and a fibronolytic agent. A tablet will be taken orally every one day with food (take immediately after meals).[1]

Glyprin is contraindicated for patients with history of sensitivity to aspirin, patients on anticoagulants or gastric irritants, active gastric intestinal ulceration or bleeding, haemophilia or other bleeding disorders, pregnancy and also lactation. Besides, Glyprin also can cause nausea, dyspepsia, vomiting, ulceration, GI mucosal erosion, haematemesis, and melaena.[1]

 

 

Patient profile

Registration no : A175460

Sex : Female

Age : 67

Weight : -

Ethnic group : Malay

Hospital : HUSM Kubang Kerian

Adverse drug reaction : First episode : Gumbleeding

                                      Second episode : Abdominal pain

 

 

Naranjo ADR probability scale

 

1. Are there previous conclusive reports on this reaction?

·         Yes. There are adverse reactions of abdominal pain (dyspepsia) and bleeding according to Malaysia Index of Medical Specialities (MIMS). [+1]

 

2. Did the adverse event appear after the suspected drug was administered?

·         Yes. According to doctor report of ADR, gumbleeding and abdominal pain were appeared immediately after administration of 100mg tablet of Glyprin. [+2]

 

 3. Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered?

·         Yes. Patient’s outcome was recovered after stop the medication. [+1]

 

4. Did the adverse reaction reappear when the drug was readministered?

·         There are no accessible information that patient was readministered again. [0]

 

5. Are there alternative causes ( other than the drug ) that could on their own have caused the reaction?

·         There are no other accessible information about patient that may cause vomiting. [0]

 

 6. Did the reaction reappear when a placebo was given?

·         There are no accessible information that patient was given placebo. [0]

 

7. Was the drug detected in the blood ( or other fluid ) in concentrations known to be toxic?

·         No accessible information. [0]

 

8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?

·         No accessible information. [0]

 

9. Did the patient have have a similar reaction to the same or similar drug in any previous reaction?

·         There is no previous history of allergies in patient. [0]

 

10. Was the adverse event confirmed by any objective evident?

·         No accessible information. [0]

 

Score for this scale assessment is +4, which means that there is a possible adverse reactions from the suspected drug (Glyprin).

 

Management

In this patient’s case, the adverse drug reactions of gumbleeding and abdominal pain are reported as mild reactions, and the adverse reactions was stopped when the treatment been stopped.  The management of adverse drug reaction is by stop the medication and the outcome is patient become recovered from adverse reactions episodes.

 

Discussion

Bleeding (gum bleeding) and abdominal pain are considered as common adverse drug reactions caused by aspirin. Whereas Glyprin, it can cause adverse reaction on gastrointestinal such as nausea, vomiting, diarrhea, and GI mucosal erosion. In case of bleeding, anticoagulant effect by aspirin can cause ulceration and gumbleeding. The adverse reactions of this drug are presented to a patient, whereby this patient had first and second episodes of drug adverse reactions. This patient has encountered gumbleeding and abdominal pain after being administered a tablet of 100mg Glyprin once daily. But when the treatment was stopped, condition (gumbleeding and abdominal pain) also disappeared. So Glyprin is a suspected drug which can cause gumbleeding and abdominal pain to this patient.

 

References

1.      Ben Yeo. MIMS. 117th ed. Hong Kong: United Medica; 2009

 


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